Nikita started karting at the age of 7, competing in championships and coming vice champion in the 2014 CIK-FIA World Karting.
He made his single seater debut in MRF Challenge during 2014. He raced in 4 races, gaining 36 points meaning he ended up 10th.
Nikita moved to Formula Renault 2.0 in the following year, joining Josef Kaufmann Racing. In the Northern European Cup, he finished 12th and in the Eurocup, he was a guest driver. In 2017, he competed again in Formula Renault 2.0 Eurocup but this time with AVF by Adrián Vallés. This time, he finished 16th behind Aleksey Korneev.
Mazepin then moved to Formula 3 European Championship, driving with Hitech Grand Prix for both years he competed. In 2016, he finished 20th in the standings and 10th in 2017. He also competed in British Formula 3, replacing Lando Norris in round 7. He finished 23rd in the standings as he only competed in 3 races.
Mazepin also made his Toyota Racing Series debut with ETEC Motorsport, finishing 18th in the standings behind Alfonso Celis Jr.
Also in the 2016 racing season, he competed in Macau Grand Prix with Hitech Grand Prix, alongside George Russell and Daniel Juncadella. Nikita qualified 18th in the qualifying race and crashed in the main race meaning he did not finish.
In the 2017 season, he competed in GP3, racing in ART with Callum Ilott, Anthoine Hubert and Jake Hughes. Together, he helped ART Grand Prix win the team’s championship and he won vice-champion in the driver’s.
In the 2019-2020 season, he also races in Formula 3 Asian championship. The championship is still ongoing but current to 16th of February 2020, he is currently 3rd in the standings.
FIA Formula 2 Championship
Nikita made his Formula 2 debut with ART Grand Prix, driving alongside Nyck de Vries. He got 5 point-paying positions gaining 11 points. He finished 18th on the standings behind Sean Gelael and ahead of Ralph Boschung.
He was confirmed to drive in Hitech, who are entering the championship for the first time, alongside Luca Ghiotto.