André started professionally karting, coming 2nd in his first championship in Torneo delle Industrie 100 Junior category. From there, he went on to compete near the top in most of the championships Lotterer raced in with 1st in 6° Trofeo Andrea Margutti, Rainbow Trophy Cadets, 7° Trofeo Andrea Margutti and 2nd in German Junior Kart Championship, German Kart Championship.
He moved up to single seaters in 1998, driving in Formula BMW Junior. Here he finished with 14 wins earning 318 points, winning his first category.
For the following year, he moved to Formula BMW ADAC and Formula Renault 2.0 Eurocup. With 15 wins out of the 18 races under his name, he won the championship with 324 points. In Eurocup, he competed with RC Motorsport to take 86 points with a win included, classifying him as 5th in the standings.
Lotterer moved to Formula 3 for 2000, competing in the German championship and the European Cup, where he competed with Opel Team BSR in both. In the German championship, André finished on the podium 7 times with 3 wins, earning 151 points, putting him in 4th place. In the European cup, he ended up finishing the race in 8th.
2001 was where André was in Formula 3 once again though this time he competed in the British version plus the singular race in the Masters of Formula 3. Out of the 25 races, he finished on the podium 5 times, collecting a win as well earning 143 points putting him in 7th place behind Andy Priaulx. For the Masters race, Lotterer finished in 3rd place for qualifying and 2nd in the main race itself behind Takuma Sato. Also during this year, he became Jaguar Racing F1 Team’s test driver.
For 2002, André moved to FIA GT Championship in the N-GT series and CART. Driving for Freisinger Motorsport in the GT series, he competed in the 7th round at Spa-Francorchamps. Lotterer finished in 3rd position earning 9 points and placing him in 19th with fellow teammate Georges Forgeois. In CART, André raced with Dale Coyne Racing, competing for the season finale in Mexico. In this race, he finished in 12th position, earning a point. Overall, he finished in 22nd behind Darren Manning.
In 2003 and 2004, Lotterer competed in the same championships, Formula Nippon and JGTC with Nakajima Racing. In his debut season, he finished with 22 points in Formula Nippon earning 3 podiums in Suzuka, Sugo and Fuji. This placed him in 5th behind Toshihiro Kaneishi. In the Japanese Grand Touring Car Championship, André finished in 16th with 19 points. He managed to gain a podium in the 7th round. The following year, the results improved. For Formula Nippon, he earned 4 podiums with 2 wins included earning 33 points, putting him in 2nd behind Briton Richard Lyons. For JGTC, Lotterer finished in 8th, claiming a win once. This meant he ended the season on 42 points finishing in the standings at 8th.
Between 2005 and 2011, he continued to race in Formula Nippon with Super GT as a supporting series. For 2005, he raced with Nakajima Racing for the last time. With 2 wins and 20 points under his name, Lotterer finished in 4th position for the championship. In his Super GT debut, he managed to stand on the podium in Fuji, putting him in 9th with Tsugio Matsuda.
2006 was his better season with TOM’S Racing. In Formula Nippon, he managed to achieve 3rd with 2 wins and 3 podiums under his name, earning 30 points. With 3 podiums and a win in Super GT, he managed to achieve 80 points putting him as the championship winner for the first time.
2007 was where he finished 5th in Nippon and 6th in GT. With 3 podiums out of the 9 races in Formula Nippon, Lotterer finished behind Satoshi Motoyama. In Super GT, André earned 54 points with a win included sharing 6th with Juichi Wakisaka.
For 2008, his results improved. 4 podiums out of the 11 races gave him 49 points, putting him 3rd position for Formula Nippon. Similarly in Super GT, he also gained 4 podiums but with 63 points also putting him in 3rd position.
Between 2008 and 2009, Lotterer competed in A1 Grand Prix, competing under Germany. In the 2 races, he retired in 1 and finished 9th in the other. With Michael Ammermüller, they put Germany in 21st behind Indonesia.
Staying with TOM’S for 2009 for both championships, André managed to achieve 3rd in Formula Nippon and 1st in Super GT, winning his second Super GT title. In Formula Nippon, Lotterer managed to earn 4 podiums with a win included, ending the season with 39 points. For Super GT, he managed to achieve 5 podiums out of the 9 races where he gained 88 points. Also during this year, he competed in the 24 hours of Le Mans with Kolles. Lotterer finished in 7th place with Charles Zwolsman Jr and Narain Karthikeyan.
In 2010, André came 2nd in the Formula Nippon championship even though he earned 7 podiums out of the 8 races with 43 points at the season end. With Super GT, he finished 2nd once again this time with 3 podiums and a win out of the 7 races with 62 points. Also during this year, Lotterer raced in the 24 hours of Le Mans with Audi Sport Team Joest. This was his first podium coming 2nd with Marcel Fässler and Benoît Tréluyer.
2011 provided a much bigger success for André Lotterer. For Formula Nippon, he finally won his first championship, winning 5 out of the 6 races and coming on the podium for all. In Super GT however, he only achieved 39 points putting him in 8th. Though in 24 hours of Le Mans, he remained with the same drivers and team to come 2nd, earning his second podium in Le Mans.
For 2012, he raced full time in FIA World Endurance with Audi Sport Team Joest and Formula Nippon. In endurance for his first full season, winning the championship with Marcel Fässler and Benoît Tréluyer. Competing again with the for Le Mans, they finished in 1st position. Along with this, he raced in Formula Nippon before it changed names to Super Formula. For its final season, he finished in 4th position with 38 points as he won 2 races and finished on the podium another time.
André raced again in FIA World Endurance and Formula Nippon for 2013. In World Endurance, he classified with 149.25 points as in the 6 hours of Fuji, the 75% race time was not completed. They finished in 2nd behind fellow team’s car of Tom Kristensen, Allan McNish and Loïc Duval. For Le Mans, his team finished in 5th position behind Toyota Racing’s number 7 car of Alexander Wurz, Nicolas Lapierre and Kazuki Nakajima. In the now renamed Super Formula, Lotterer earned 2 wins and 4 podiums out of the 4 races, giving him 37 points and 2nd in the standings.
Staying with Audi, André finished in 2nd place for endurance, earning 161 points and winning 2 of the races. This placed him 2nd with his team. However, for the Le Mans race, he finished in 1st, winning his third Le Mans race and third with the team. Including this, Lotterercompeted in another season of Super Formula, coming 3rd with 34.5 points as he scored 4 podiums with 2 wins inclusive in 8 races. Also during this year, he raced with Caterham Racing in Formula One during the Belgium round though retired in the race.
Again staying with the same teams, Lotterer ended up 2nd with 2 wins in Silverstone and Spa though claimed 8 podiums out of the 8 races, with a 3rd included from Le Mans. For Super Formula, André won 3 races out of the 8 putting 40 points under his name and classifying him in 3rd.
For 2016, Lotterer rejoined Audi Sport Team Joest with the same pairings from previous years. With 3 podiums in Nürburgring, Mexico and Bahrain, he scored 104 points putting him in 5th position behind Porsche’s team. In this year’s Le Mans, he was close to a podium in 4th behind Audi’s other car. In Super Formula, Lotterer once again stayed with TOM’S to finish 2nd in the standings with 3 podiums.
2017 is where André moved teams for FIA World Endurance Championship, joining Porsche LMP Team and becoming one of their factory drivers. In the main standings he finished on the podium 7 times earning 129 points, classifying at 4th. One of the races he didn’t finish on the podium was Le Mans where the team didn’t finish due to a mechanical issue. For Super Formula, Lotterer finished in 6th position with 20 points as he won a race and got 3 podiums out of the 7 races. André made his Blancpain debut in the endurance cup with Audi Sport Team WRT driving in the 24 hours of Spa round with Marcel Fässler and Dries Vanthoor. For the single round, he wasn’t in the points paying positions during the 6th, 12th and 24th hour meaning he wasn’t classified in the standings. Similarly, he raced in the Intercontinental GT Challenge with Audi, driving in the 24 hours of Spa as well, though here he finished in 11th so was unable to claim any points, leaving him unclassified.
For FIA World Endurance, the first Le Mans race in 2018, Lotterer finished in 4th with Rebellion Racing behind fellow Rebellion car of Thomas Laurent, Gustavo Menezes and Mathias Beche. In the second Le Mans race in 2019, André finished in 4th again this time behind SMP’s car of Mikhail Aleshin, Vitaly Petrov and Stoffel Vandoorne. For the entire FIA World Endurance championship, Lotterer finished 5th in the standings with 91 points.
André made his debut in Formula E with Techeetah, racing with them for the season in 2017/2018. In Santiago 2018, he helped Techeetah earn a 1-2, the first ever in Formula E history. He also claimed another podium in the Rome ePrix. Lotterer finished the season in 8th with 64 points, behind Mitch Evans. Techeetah missed out on the team’s title by 2 points.
Lotterer rejoined DS Techeetah for the 2018/2019 season, driving with Jean-Éric Vergne. He was close to winning in the Hong Kong ePrix but got a puncture during a shunt with Sam Bird. However in the season, he had a podium in Rome and Paris. For this season, he ended up with 86 points, putting him in 8th behind fellow German Daniel Abt. His points plus the points from Vergne put Techeetah in 1st, winning their first teams championship in their second season.