Vandoorne started his karting career in 2008 where he won his first title in the 2008 KF2 Belgian Championship. From there, he took second in the 2009 KF2 CIK-FIA World Cup before finishing off his karting years in 2010. Stoffel then graduated to the F4 Eurocup 1.6 in the later months of 2010 where he won the championship. From there, he moved to the Formula Renault 2.0 Eurocup in 2011 where he finished fifth with KTR and the Formula Renault 2.0 NEC where he finished 3rd with 8 podiums. Vandoorne returned back to Eurocup Formula Renault 2.0 for a second year with Josef Kaufmann
Racing where he took 11 podiums, of which four were wins, along wish 6 pole positions. He also joined the team in the Formula Renault 2.0 NEC for 2012 where he took 5 wins and another podiums to place him 9th in the standings. In 2013, he joined Fortec Motorsport in his rookie year of Formula Renault 3.5 Series where out of 17 races, he took 4 wins and a further 6 podiums to finish runner up in the standings.
Stoffel then made his debut in the GP2 Series in 2014 with ART Grand Prix where he took 6 podiums with 4 wins and 229 points to finish runner up in the standings of his rookie year. He returned with the team for 2015 where he took 16 podiums, of which 7 were wins, and 341.5 points to place him 1st in the standings. He then made the move to Super Formula with Docomo Team Dandelion Racing for 9 races where he took two wins and another podium to place him 4th in the standings.
In the 2018 to 2019 Series of the FIA World Endurance Championship, Vandoorne joined SMP Racing for his rookie year where he raced in two races and scored a podium in both, placing him 11th in the standings. He also competed in the 24 Hours of Le Mans with the team where he finished 3rd.
Vandoorne debuted in Formula One when he joined McLaren Mercedes in 2014 as the Test Driver. He continued with the team for a second year in 2015 when the team changed to McLaren Honda. Headfing into 2016, Stoffel joined McLaren Honda for a single race before competing full time in 2017. He took 13 points in his rookie year and 16th in the standings. He finished in 16th once again in 2018 with 12 points. Vandoorne returned to Formula One in 2019 where he joined Mercedes-AMG Petronas as a development driver. For the upcoming 2020 season, Stoffel will become the reserve driver for Mercedes.
Stoffel Vandoorne debuted in FIA Formula E during the 2018 to 2019 Series with HWA Racelab. He took a single podium in his rookie year and finished 16th in the standings.